Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments
نویسندگان
چکیده
منابع مشابه
Different cell fates after mitotic slippage: From aneuploidy to polyploidy
The molecular mechanism responsible for cell fate after mitotic slippage remains unclear. We investigated the different postmitotic effects of aneuploidy versus polyploidy using chemical inhibitors of centromere-associated protein-E (CENP-E) and kinesin family member 11 (KIF11, also known as Eg5). Aneuploidy caused substantial proteotoxic stress and DNA damage accompanied by p53-mediated postmi...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2021
ISSN: 1350-9047,1476-5403
DOI: 10.1038/s41418-021-00745-8